K16: Knows the structural mechanisms and systems involved in the immune response, and the functioning and development of the nervous system. S1: Uses a variety of techniques to find, manage, integrate and critically evaluate available information for the development of professional activities in Neuroscience, especially in the digital sphere S4: Uses their ability to analyse and synthesise, as well as to apply the principles of the scientific method in the work environment, in order to provide innovative responses to the needs and demands of society in their area. S5: Appropriately uses the scientific and technical vocabulary of the different subfields within Neuroscience. S6: Has an understanding of the biological bases of pathologies of the nervous system, as well as the biological and socio-economic effects these pathologies have on the lives of people who suffer from them. C1: Apply knowledge about the biological basis of Central Nervous System (CNS) disorders and their effects to the development of improved diagnostics and treatments. C5: Apply your neuroscience knowledge in a unifying and integrated fashion as part of a multidisciplinary team (pharmaceutical sector, health industry, diagnostic techniques, health information technologies, government agencies and regulatory bodies. C6: Apply the results of your comprehensive training to your everyday professional activities, combining Neuroscience knowledge with a solid foundation of ethical responsibility and respect for fundamental rights, diversity and democratic values. C7: Apply the scientific and technical principles you acquired during your undergraduate training, together with your own natural learning capabilities, to better adapt to novel opportunities arising from scientific and technological development.

1. Review of the main aspects of the Innate and Adaptive Immune Response. Innate and antigen-specific responses. The immune system and pathology. Immunodeficiency, autoimmunity, allergy and cancer. 2. Inflammation. Concept and development. Inflammatory cells and molecules. Signalling and extravasation mechanisms. Amplification and acute phase response. Chronic inflammation, negative regulation of inflammation and tissue repair. Detection and diagnostic evaluation of inflammation. 3. Response to infection. General overview of the immune response against pathogens. Mechanisms of evasion. 4. Immune response to viruses. 5. Immune response against extracellular bacteria. 6. Immune response against intra-cellular bacteria. 7. Immune response against fungi. 8. Immune response against parasites. 9. Tumour immunology. Cancer, origin and terminology. Malignant transformation. Evasion of the immune response. Cancer immunotherapy, immunological check-points. 10. Autoimmunity. Mechanisms of tolerance. Aetiology of autoimmune diseases. Characteristics and types of autoimmune diseases. Therapies. 11. Allergy. Concept of allergy and atopy. Basic mechanisms. Main allergic diseases, diagnosis of allergic diseases. 12. Transplantation immunology. Histocompatibility studies. Mechanisms of rejection, prevention and treatment of transplanted organ rejection. 13. Immunodeficiency Mechanisms of immunodeficiency. Study of immunodeficiencies. Therapy of immunodeficiencies. 14. Immunotherapy. Vaccines, cytokines, chemokines, monoclonal antibodies. 15. Cellular therapies.

Classroom lectures. Face-to-face classes: reduced (workshops, seminars, case studies). Student individual work. Laboratory session. Final exam. Seminars and lectures supported by computer and audiovisual aids. Practical learning based on cases and problems, and exercise resolution. Individual and group or cooperative work with the option of oral or written presentation. Individual and group tutorials to resolve doubts and queries about the subject. Internships and directed laboratory activities.