1. Review of the main aspects of the Innate and Adaptive Immune Response. Innate and antigen-specific responses. The immune system and pathology. Immunodeficiency, autoimmunity, allergy and cancer.
2. Inflammation. Concept and development. Inflammatory cells and molecules. Signalling and extravasation mechanisms. Amplification and acute phase response. Chronic inflammation, negative regulation of inflammation and tissue repair. Detection and diagnostic evaluation of inflammation.
3. Response to infection. General overview of the immune response against pathogens. Mechanisms of evasion.
4. Immune response to viruses.
5. Immune response against extracellular bacteria.
6. Immune response against intra-cellular bacteria.
7. Immune response against fungi.
8. Immune response against parasites.
9. Tumour immunology. Cancer, origin and terminology. Malignant transformation. Evasion of the immune response. Cancer immunotherapy, immunological check-points.
10. Autoimmunity. Mechanisms of tolerance. Aetiology of autoimmune diseases. Characteristics and types of autoimmune diseases. Therapies.
11. Allergy. Concept of allergy and atopy. Basic mechanisms. Main allergic diseases, diagnosis of allergic diseases.
12. Transplantation immunology. Histocompatibility studies. Mechanisms of rejection, prevention and treatment of transplanted organ rejection.
13. Immunodeficiency Mechanisms of immunodeficiency. Study of immunodeficiencies. Therapy of immunodeficiencies.
14. Immunotherapy. Vaccines, cytokines, chemokines, monoclonal antibodies.
15. Cellular therapies.
