Checking date: 24/04/2024

Course: 2024/2025

Fundamentals of tissue engineering and regenerative medicine
Bachelor in Engineering Physics (Plan: 434 - Estudio: 363)

Coordinating teacher: GUERRERO ASPIZUA, SARA

Department assigned to the subject: Bioengineering Department

Type: Electives
ECTS Credits: 6.0 ECTS


Requirements (Subjects that are assumed to be known)
The student must have coursed Cell and Molecular Biology and Biochemistry.
Tissue engineering (TE) is a multidisciplinary field which applies the principles of life science, engineering, and basic science to the development of viable substitutes which restore, maintain, or improve the function of human tissues. This course is designed to provide a basic knowledge of Tissue and organ organization and an introduction to tissue engineering: Dynamic and structural interactions between mesenchyme and parenchyme, the role of the tissue microenvironment, stem cells, gene and cell-based therapies. Students will be required to acquire understanding and expertise from analysis of primary literature and will participate in group discusions on the status of state-of-the-art designing tissue functional units. Students will be required to use a conventional and virtual microscope to recognize and document normal and pathological structures. Students will be required to follow a SPOC (small private online course) that will intensify the knowledge acquired through the continuous evaluation. The students will carry out audiovisual presentations as a result of their research in fields related to regenerative medicine.
Skills and learning outcomes
CB1. Students have demonstrated possession and understanding of knowledge in an area of study that builds on the foundation of general secondary education, and is usually at a level that, while relying on advanced textbooks, also includes some aspects that involve knowledge from the cutting edge of their field of study. CB2. Students are able to apply their knowledge to their work or vocation in a professional manner and possess the competences usually demonstrated through the development and defence of arguments and problem solving within their field of study. CB3. Students have the ability to gather and interpret relevant data (usually within their field of study) in order to make judgements which include reflection on relevant social, scientific or ethical issues. CB4. Students should be able to communicate information, ideas, problems and solutions to both specialist and non-specialist audiences. CB5. Students will have developed the learning skills necessary to undertake further study with a high degree of autonomy. CG2. Learn new methods and technologies from basic scientific and technical knowledge, and being able to adapt to new situations. CG3. Solve problems with initiative, decision making, creativity, and communicate and transmit knowledge, skills and abilities, understanding the ethical, social and professional responsibility of the engineering activity. Capacity for leadership, innovation and entrepreneurial spirit. CG4. Solve mathematical, physical, chemical, biological and technological problems that may arise within the framework of the applications of quantum technologies, nanotechnology, biology, micro- and nano-electronics and photonics in various fields of engineering. CG5. Use the theoretical and practical knowledge acquired in the definition, approach and resolution of problems in the framework of the exercise of their profession. CG6. Develop new products and services based on the use and exploitation of new technologies related to physical engineering. CG7. Undertake further specialized studies, both in physics and in the various branches of engineering. CT1. Work in multidisciplinary and international teams as well as organize and plan work making the right decisions based on available information, gathering and interpreting relevant data to make judgments and critical thinking within the area of study. RA1. To have acquired sufficient knowledge and proved a sufficiently deep comprehension of the basic principles, both theoretical and practical, and methodology of the more important fields in science and technology as to be able to work successfully in them. RA2. To be able, using arguments, strategies and procedures developed by themselves, to apply their knowledge and abilities to the successful solution of complex technological problems that require creating and innovative thinking. RA3. To be able to search for, collect and interpret relevant information and data to back up their conclusions including, whenever needed, the consideration of any social, scientific and ethical aspects relevant in their field of study. RA4. To be able to successfully manage themselves in the complex situations that might arise in their academic or professional fields of study and that might require the development of novel approaches or solutions. RA6. To be aware of their own shortcomings and formative needs in their field of specialty, and to be able to plan and organize their own training with a high degree of independence.
Description of contents: programme
Obtain an overview of tissue engineering in clinical medicine and biomedical research Understand the role of emerging technologies and engineering and life science disciplines in tissue engineering 1) Review of current status of tissue engineering and regenerative medicine Introduction to TE and overview of course objectives 2) Tissues morphological and functional units Organization of cell into higher ordered structures Dynamics of Cell-ECM Interactions Analysis of the physicochemical processes that affect limit and control cells and tissues function. - Epithelial Tissue, Connective Tissue, Muscular Tissue and Nervous Tissue 3) Systems and Organs: morphological and functional units Structural and dynamic interactions between mesenchyme and parenchyma The role of tissue microenvironment, extracellular matrix and communication by growth factors 4) Tegumentary System 5) Designing tissue functional units Stem cells and Genetic Engineering 6) Seminars on tissue recognition using virtual microscope. 7) "SPOC" about tissue engineering and regenerative medicine that wil firm up the continuous evaluation contents. 8) Audiovisual material preparation based on regenerative medicine. LABORATORY EXPERIMENTS: (Every student will perform 15 hours of practical sessions in UC3M bioengineering laboratories) a. Use of conventional microscopy for the understanding of tissue structure. b. Understand microscopic organization of Tissues into Organs and systems. c. Tissue observation and image capture. Tissue engineering. d. Histology as a diagnostic tool. e. Use of Immunohistochemical techniques.
Learning activities and methodology
The program will be divided into master classes (regular and invited lectures), discussion/problem classes (seminars) virtual microscope seminars, and the students will course a SPOC (small private online course), audiovisual material preparation based in Regenerative medicine and finally laboratory classes. Students are required to read assigned chapters/articles, or solve problems before the corresponding classes. In the discussion and problems sections, relevant scientific articles and problems will be discussed by the students and the teaching team. In the laboratory sessions students, divided in small groups will perform different experiments with the help of a supervisor and Lab guide prepared by the teaching team. Students will be required to pass an exam at the end of laboratory sessions.
Assessment System
  • % end-of-term-examination 60
  • % of continuous assessment (assigments, laboratory, practicals...) 40

Calendar of Continuous assessment

Extraordinary call: regulations
Basic Bibliography
  • Langer, Robert S, Lanza, R. P., and Vacanti, Joseph. Principles of Tissue Engineering. 4th ed. . Elsevier. 2014
  • Mescher, Anthony L. . Junqueira's Basic Histology : Text and Atlas. 15th Ed.. McGraw-Hill. 2018
  • Micou, Melissa Kurtis, and Dawn M. Kilkenny. A Laboratory Course in Tissue Engineering.. CRC Press. 2013
Additional Bibliography
  • Fawcett, Don W., and Ronald P. Jensh. Bloom and Fawcett's Concise Histology. 2nd ed. . Arnorld. 2002
  • Saltzman, W. Mark. . Tissue Engineering Engineering Principles for the Design of Replacement Organs and Tissues.. Oxford OP. 2004
Detailed subject contents or complementary information about assessment system of B.T.

The course syllabus may change due academic events or other reasons.