Description of contents: The goals of the course are to understand the fundamentals and applications of massive omic technologies in biomedicine, to learn the importance of the application of omic technologies (generation and analysis of massive biological data) to solve complex problems in Biomedicine and to be familiarized with these technologies and develop criteria to apply them to the resolution of specific problems.
At the end of the course, students should be able to:
a. Learn the basis behind omic technologies.
b. Design experiments using these technologies depending on the biomedical problem: selection of the appropiate methodology and platform.
c. Bioinformatic treatment of the generated data to evaluate the quality of the process.
d. Understand the design, components, arquitecture and software of the equipment involved in the different technologies.
"Omic technologies" programme:
a. Introduction to new generation omic technologies.
b. Next Generation Sequencing. Description of existing platforms and others in development.
c. Transcriptomics. Microarrays and RNA-Seq. Different types (genotyping, CGH...)
d. Proteomics. Description of advanced high throughput tools for the analysis of proteins: bidimensional electrophoresis (2D-DIGE), mass spectrometry (ESI, MALDI, MALDI-TOF, MALDI TOF /TOF, NLC MS/MS, etc.)
e. Metabolomics. Methods for quantitative measurement of the metabolic response in living organisms. NMR and mass spectrometry.
f. Application of computing and information technologies to the treatment of biological data
g. Components, architecture, software and performance of the most relevant appliances
h. Computer practices and/or visits to hospitals or related companies: tecnological analysis of the most relevant appliances.