Checking date: 26/07/2023


Course: 2023/2024

Biomedical Microdevices
(15564)
Bachelor in Biomedical Engineering (Plan: 419 - Estudio: 257)


Coordinating teacher: MUÑOZ BARRUTIA, MARIA ARRATE

Department assigned to the subject: Bioengineering Department

Type: Electives
ECTS Credits: 6.0 ECTS

Course:
Semester:




Requirements (Subjects that are assumed to be known)
It is strongly advised to have completed: - Introduction to the design of biomedical instrumentation; and - Medical instrumentation and devices.
Objectives
This course aims to provide the students with a comprehensive understanding of the biophysical and chemical principles of biomedical micro-electro-mechanical systems, also known as BioMEMS, and their applications in multidisciplinary fields such as medicine and clinical sciences and surgery, material sciences, and engineering. The study of the basis of microfabrication techniques, micropatterning, microfluidic systems, and biosensors will be completed with examples of current applications of BioMEMS such as biomechanical, optical, and electrochemical transducers used for in vivo and in vitro measurements, microdevices for molecular and cell biology, microfabricated approaches for analysis and diagnosis, hybrid technologies oriented to tissue microengineering and organ development, implantable microdevices based on biomedical microelectronics, micro-tools for surgery, point-of-care devices and world-to-chip interfacing and packaging processes. In particular, at the end of the course, each student will be able to: - Integrate knowledge of life and medical science learned in previous courses to create implementable solutions to microengineering problems. - Select appropriate materials for the construction of biomedical microdevices. - Understand the basic principles of microfabrication and systems integration of BioMEMS devices. - Design and construct simple microfluidic systems and perform experiments using these devices. - Describe different biosignal transduction mechanisms and choose the appropriate one for a given application. - Have an appreciation and understanding of the technical challenges and opportunities that biomedical microdevices bring to life and medical sciences. - Function effectively as a part of a group in the practical sessions and problem-solving sessions. - Acquire through reading, practice exercises, and self-initiated research technical knowledge related to the course content, including the emerging applications of biomedical microdevices.
Skills and learning outcomes
Description of contents: programme
1. Introduction Part I. BioMEMS fundamentals 2. BioMEMS Materials 3. Microfabrication methods and processes for BioMEMS 4. Microfluidic systems 5. Lab-on-a-Chip or Micro Total Analysis Systems 6. Sensing and detection methods Part II. BioMEMS applications 7. 'Chips' for or biotechnology and molecular biology 8. BioMEMS for cell biology 9. Clinical monitoring and therapeutic intervention Part III. Practical sessions 1. Design of a PDMS microdevice 2. PDMS microdevices fabrication and characterization 3. Paper microfluidics design and characterization 4. Glucometer design and calibration 5. Flexible electronics 6. Analysis of flow cytometer data
Learning activities and methodology
The teaching methodology will be mainly based on lectures, seminars, and practical sessions. LECTURES: Due to the large number of topics covered and their multidisciplinary nature, it is very convenient that the student read the assigned documentation before the lectures and, when required, complement it provided with additional information through personal work. 1) Lectures: The teachers will use them to stress and clarify some challenging and exciting points from the corresponding lesson previously prepared by the student. 2) Seminars: They will be mainly dedicated to presentations given by invited speakers related to the course subject and interactive discussions with the students. During the discussion sessions, exercises will be provided and solved in small groups of 2-3 students. On some occasions, the activities will be assigned as homework. All assignments are due by the corresponding deadline through the course platform. 3) Oral presentations: At least once during the course, each student will have the chance to do a short oral presentation on a topic related to the course. These oral presentations will be prepared individually or in groups of two and have a duration of approximately 15 minutes per student. Help sessions and tutorial classes will be held before the final exam. Attendance to lectures, short exams, or submission of possible homework is not compulsory. PRACTICAL SESSIONS: The practical sessions may include visits to research, clinical centers, or laboratory work. 1) Visits to research or clinical centers: These visits to centers designing, fabricating, or using bioMEMS will aim to expose the students to the practicalities of the subject. The students will prepare a short report about the visit to consolidate the learned concepts. 2) Laboratory practices: Each experiment will be performed in groups of no more than three students for these sessions. Simple experiments will familiarize the students with BioMEMS devices during these sessions. Experimental data will be obtained, analyzed, and presented as a scientific report. Attendance to practical sessions is mandatory. Tutorship sessions and schedules will be announced in Aula Global.
Assessment System
  • % end-of-term-examination 40
  • % of continuous assessment (assigments, laboratory, practicals...) 60
Calendar of Continuous assessment
Basic Bibliography
  • Albert Folch. Introduction to BioMEMS. CRC Press. 2013
  • Albert Folch. Hidden in Plain Sight. The MIT Press. 2022
  • Ellis Meng. Biomedical Microsystems. CRC Press. 2011
Additional Bibliography
  • Simona Badilescu, Muthukumaran Packirisamy. BioMEMS: Science and Engineering Perspectives. CRC Press. 2016
  • Stephen D. Senturia. Microsystems Design. Kluwer Academic Publishers. 2001

The course syllabus may change due academic events or other reasons.