Checking date: 17/05/2023

Course: 2023/2024

Fundamental of tissue engineering and regenerative medicine
Bachelor in Biomedical Engineering (Plan: 419 - Estudio: 257)

Coordinating teacher: GUERRERO ASPIZUA, SARA

Department assigned to the subject: Bioengineering Department

Type: Compulsory
ECTS Credits: 6.0 ECTS


Requirements (Subjects that are assumed to be known)
The student must have coursed Cell and Molecular Biology and Biochemistry.
Tissue engineering (TE) is a multidisciplinary field which applies the principles of life science, engineering, and basic science to the development of viable substitutes which restore, maintain, or improve the function of human tissues. This course is designed to provide a basic knowledge of Tissue and organ organization and an introduction to tissue engineering: Dynamic and structural interactions between mesenchyme and parenchyme, the role of the tissue microenvironment, stem cells, gene and cell-based therapies. Students will be required to acquire understanding and expertise from analysis of primary literature and will participate in group discusions on the status of state-of-the-art designing tissue functional units. Students will be required to use a conventional and virtual microscope to recognize and document normal and pathological structures. Students will be required to follow a SPOC (small private online course) that will intensify the knowledge acquired through the continuous evaluation. The students will carry out audiovisual presentations as a result of their research in fields related to regenerative medicine.
Skills and learning outcomes
Description of contents: programme
Obtain an overview of tissue engineering in clinical medicine and biomedical research Understand the role of emerging technologies and engineering and life science disciplines in tissue engineering 1) Review of current status of tissue engineering and regenerative medicine Introduction to TE and overview of course objectives 2) Tissues morphological and functional units Organization of cell into higher ordered structures Dynamics of Cell-ECM Interactions Analysis of the physicochemical processes that affect limit and control cells and tissues function. - Epithelial Tissue, Connective Tissue, Muscular Tissue and Nervous Tissue 3) Systems and Organs: morphological and functional units Structural and dynamic interactions between mesenchyme and parenchyma The role of tissue microenvironment, extracellular matrix and communication by growth factors 4) Tegumentary System 5) Designing tissue functional units Stem cells and Genetic Engineering 6) Seminars on tissue recognition using virtual microscope. 7) "SPOC" about tissue engineering and regenerative medicine that wil firm up the continuous evaluation contents. 8) Audiovisual material preparation based on regenerative medicine. LABORATORY EXPERIMENTS: (Every student will perform 15 hours of practical sessions in UC3M bioengineering laboratories) a. Use of conventional microscopy for the understanding of tissue structure. b. Understand microscopic organization of Tissues into Organs and systems. c. Tissue observation and image capture. Tissue engineering. d. Histology as a diagnostic tool. e. Use of Immunohistochemical techniques.
Learning activities and methodology
The program will be divided into master classes (regular and invited lectures), discussion/problem classes (seminars) virtual microscope seminars, and the students will course a SPOC (small private online course), audiovisual material preparation based in Regenerative medicine and finally laboratory classes. Students are required to read assigned chapters/articles, or solve problems before the corresponding classes. In the discussion and problems sections, relevant scientific articles and problems will be discussed by the students and the teaching team. In the laboratory sessions students, divided in small groups will perform different experiments with the help of a supervisor and Lab guide prepared by the teaching team. Students will be required to pass an exam at the end of laboratory sessions.
Assessment System
  • % end-of-term-examination 60
  • % of continuous assessment (assigments, laboratory, practicals...) 40
Calendar of Continuous assessment
Basic Bibliography
  • Langer, Robert S, Lanza, R. P., and Vacanti, Joseph. Principles of Tissue Engineering. 4th ed. . Elsevier. 2014
  • Mescher, Anthony L. . Junqueira's Basic Histology : Text and Atlas. 15th Ed.. McGraw-Hill. 2018
  • Micou, Melissa Kurtis, and Dawn M. Kilkenny. A Laboratory Course in Tissue Engineering.. CRC Press. 2013
Additional Bibliography
  • Fawcett, Don W., and Ronald P. Jensh. Bloom and Fawcett's Concise Histology. 2nd ed. . Arnorld. 2002
  • Saltzman, W. Mark. . Tissue Engineering Engineering Principles for the Design of Replacement Organs and Tissues.. Oxford OP. 2004
Detailed subject contents or complementary information about assessment system of B.T.

The course syllabus may change due academic events or other reasons.