Checking date: 14/07/2020

Course: 2020/2021

Introduction to the design of medical instrumentation
Study: Bachelor in Biomedical Engineering (257)

Coordinating teacher: GOMEZ CID, LIDIA

Department assigned to the subject: Department of Bioengineering and Aerospace Engineering

Type: Compulsory
ECTS Credits: 6.0 ECTS


Students are expected to have completed
Introduction to bioengineering Electronic technology in biomedicine Measuring instrumentation Signals and Systems o Digital Signal Processing
Competences and skills that will be acquired and learning results. Further information on this link
The student that successfully finishes this course should understand the biomedical application, specify the user and technical specifications, and provide a complete protocol for the design of a medical instrument, and to analyse the signals and data generated by the the instrument. Besides, after the completion of this course the student should be able to implement a functioning medical instrument using state-of-the-art electronics and sensor technologies. Special attention will be paid to safety and regulatory aspects applied to biomedical instrumentation.
Description of contents: programme
1. Basic concepts on biomedical instrumentation 1.1. Design cycle protocol 1.2. Regulations and marking 2. Electrical safety 2.1. Physiological Effects of Electricity 2.2. Concept of "ground" in biomedical instruments 2.3. Isolated instruments and batteries 3. Origin of Biopotentials. Techniques to record Biopotentials 3.1. Principles of bioelectricity 3.2. Transmembrane Action Potential 3.3. Transmembrane Resting Potential 3.4. Ion Channels, Pumps and Exchangers 4. Electrocardiology. ECG characteristics 4.1. Anatomy and Physiology of the Heart 4.2. Electrophysiological Cardiac Behavior 4.3. Cardiac Transmembrane Action Potential 4.4. The electrocardiogram (ECG) 4.5. Diagnosis based on the ECG 4.6. Recording the ECG 4.7. Invasive Cardiac Mapping Instruments 5. Signal amplification 5.1. Operational Amplifiers and applications 5.2. Output and Input Impedance 5.3. Instrumentation amplifiers 6. Signal filtering 6.1. Frequency domain 6.2. Ideal Filters 6.3. Dealing with the Noise 6.4. Passive Analog Filters 6.5. Active Analog Filters 7. Electrodes and Electrolytes 7.1. Oxidation and reduction 7.2. Polarizable and Nonpolarizable Electrodes 7.3. Electrode Behavior and Circuit Models 8. Sensors: biophysics, design, applications 8.1. Resistive sensors 8.2. Capacitive sensors 8.3. Piezoelectric Sensors 8.4. Thermocouples 8.5. Wheatstone Bridge 9. Electroencephalogram and Magnetroencephalogram 9.1. Action potentials in Neurons 9.2. Electric and Magnetic Fields in the brain 9.3. Electroencephalography (EEG) 9.4. Magnetoencephalography: MEG 9.5. EEG and MEG signals and applications 10. Electromyogram, electroneurogram, electrooculogram and electroretinogram 10.1. Electromyogram (EMG): Principles, instrumentation and applications 10.2. Electroneurogram (ENG): Principles, instrumentation and applications 10.3. Electrooculogram (EOG): Principles, instrumentation and applications 10.4. Electroretinogram (ERG): Principles, instrumentation and applications 11. Implantable devices 11.1. Cardiac Pacemakers 11.2. Brain Pacemakers 11.3. Defibrillators. 12. Optical and light based measurement system 12.1. Basis of Light Propagation in Tissues 12.2. Light Scattering 12.3. Light Absorption 12.4. Optical Contrast Agents 13. Introduction to Digital Signal Processing 13.1. Analog-to-digital converter 13.2. Digital Frequency 13.3. Digital Filtering 13.4. Changing sampling rate 13.5. Spectral estimation 14. Applications of Digital Signal Processing 14.1. Preprocessing signals 14.2. Automatic detection of events 14.3. Classification of events 14.4. Nonlinear analysis of a sequence of events 15. Biomedical signal acquisition and processing with LabView or Matlab 15.1. Data structures and analysis 15.2. LabVIEW or Matlab environment 15.3. Data acquisition with LabVIEW or Matlab
Learning activities and methodology
Teaching methodology will be mainly based on lectures, seminars and practical sessions. Lectures will be used by the teachers to present the main concepts of the course. Seminars will be mainly dedicated to interactive discussion with the students and to stress and clarify the most interessing and difficult points. Deliverable exercises and presentations will be done during the sessions. Grading will be based on continuous evaluation (including a partial exam, practical sessions, and student participation in class and Aula Global) and a final exam covering the whole subject. Help sessions and tutorial classes will be held prior to the final exam. Attendance to lectures, short-exams or submission of possible homework is not compulsory. However, failure to attend any exam or submit the exercises before the deadline will result in a mark of 0 in the corresponding continuous evaluation block. The practical sessions will consist on laboratory work and visits to research or clinical centers. A laboratory report will be required for each of them. The attendance to practical sessions is mandatory. Failure to hand in the laboratory reports on time or unjustified lack of attendance will result in 0 marking for that continuous evaluation block.
Assessment System
  • % end-of-term-examination 50
  • % of continuous assessment (assigments, laboratory, practicals...) 50
Basic Bibliography
  • J.G. Webster. Medical Instrumentation Application and Design. John Wiley and Sons, Inc..
  • L.A. Geddes and L.E. Baker. Principles of Applied Biomedical Instrumentation. John Wiley and Sons, Inc..
Additional Bibliography
  • A.F. Arbel. Analog Signal Processing and Instrumentation. Cambridge University Press.
  • J.B Olansen, E. Rosow. Virtual Bio-Instrumentation. Prentice Hall PTR.
  • L. Cromwell, F.J. Weibell, E.A. Pfeiffer. Biomedical Instrumentation and Measurements. Prentice Hall Career & Technology.
  • R. Sarpeshkar. Ultra Low Power Bioelectronics. Cambridge University Press.

The course syllabus and the academic weekly planning may change due academic events or other reasons.