Checking date: 19/12/2023


Course: 2023/2024

Cell and molecular biology
(15532)
Bachelor in Biomedical Engineering (Plan: 419 - Estudio: 257)


Coordinating teacher: RIO NECHAEVSKY, MARCELA ANDREA DEL

Department assigned to the subject: Bioengineering Department

Type: Basic Core
ECTS Credits: 6.0 ECTS

Course:
Semester:

Branch of knowledge: Engineering and Architecture



Requirements (Subjects that are assumed to be known)
Introduction to bioengineering
Objectives
Students will become familiar with the principles governing cell and tissue function and the alterations at the base of human diseases. They will also study and use modern cellular and molecular techniques that allow us to analyze cell function. Students will also learn how to raise biomedical problems, seek and use relevant information and find innovative solutions to them, taking into account the different biological and engineering tools that are taught in this degree. To do this, they will have to work in cooperative teams. They will also have the opportunity to get in touch, in hospitals and biomed/biotech companies, with actual problems and the solutions and limitations of existing technologies.
Skills and learning outcomes
RA1: Acquire knowledge and understanding of the basic general fundamentals of engineering and biomedical sciences. RA2: Be able to solve basic engineering and biomedical science problems through a process of analysis, identifying the problem, establishing different methods of resolution, selecting the most appropriate one and its correct implementation. CB1: Students have demonstrated possession and understanding of knowledge in an area of study that builds on the foundation of general secondary education, and is usually at a level that, while relying on advanced textbooks, also includes some aspects that involve knowledge from the cutting edge of their field of study. CB2: Students are able to apply their knowledge to their work or vocation in a professional manner and possess the competences usually demonstrated through the development and defence of arguments and problem solving within their field of study. CG1: Adequate knowledge and skills to analyse and synthesise basic problems related to engineering and biomedical sciences, solve them and communicate them efficiently. CG3: Knowledge of basic scientific and technical subjects that enables them to learn new methods and technologies, as well as providing them with great versatility to adapt to new situations. CG4: Ability to solve problems with initiative, decision-making, creativity, and to communicate and transmit knowledge, skills and abilities, understanding the ethical, social and professional responsibility of the biomedical engineer's activity. Capacity for leadership, innovation and entrepreneurial spirit. CG8: Ability to solve mathematical, physical, chemical and biochemical problems that may arise in biomedical engineering. CG13: Knowledge of the fundamental principles of molecular, cellular, structural and biochemical biology applied to human beings. ECRT6: Acquire a vision of biological systems at the cellular and molecular level and apply them to the resolution of problems in biomedicine and biotechnology. CT1: Ability to communicate knowledge orally and in writing to both specialised and non-specialised audiences.
Description of contents: programme
To understand biological materials and systems and design new ways to repair or replace them, it is imperative to understand their cellular and molecular components and functions. Cell and Molecular Biology form the foundation of biotechnology and biomedical industry today. This course covers a detailed analysis of the structures, mechanisms and molecules that control cell function, proliferation and differentiation as well as the changes that lead to pathological conditions. It also teaches, both in master and laboratory classes, modern molecular techniques to analyze cell function. PROGRAMME: CELL BIOLOGY 1. Chemical components of the cell. 2. Cell compartments 3. Membrane Structure 4. Membrane Transport 5. Vesicular Traffic MOLECULAR BIOLOGY 6. Protein Structure and Function 7. From DNA to Genes to Genomes. Genomics. 8. From DNA to Proteins. Transcriptomics and Proteomics 9. Control of cell expression 10. Control of gene expression LABORATORY EXPERIMENTS: 1. Plasmid DNA Isolation. 2. Restriction Digestion. Plasmid Maps. 3. Ligation and Transformation. 4. Cell Culture.
Learning activities and methodology
The program will be divided into lectures (master class) and paper discussion/problem sessions (small class size) and laboratory practical classes. Students are required to read or resolve assigned chapters, articles, problems, etc., before or during the corresponding classes.
Assessment System
  • % end-of-term-examination 40
  • % of continuous assessment (assigments, laboratory, practicals...) 60
Basic Bibliography
  • Bruce Alberts et al.. Essential Cell Biology, 3rd Edition. Ed. Garland Publishing, Inc. New York and London.
  • Harvey Lodish et al.. Molecular Cell Biology, 5th Edition. Ed. Freeman and Company, New York..
  • J. Sambrook, E.F. Fritash and T. Maniatis.. Molecular Cloning: A laboratory Manual, 3rd Edition.. Ed. Cold Spring Harbour Press..
  • Jennie P. Mather and David Barned.. Animal Cell Culture Methods.. Ed. Associated Press.
  • John D. Bancroft and Marilyn Gamble.. Theory and Practice of Histological Techniques. . 5th edition.

The course syllabus may change due academic events or other reasons.