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Course: 2021/2022

Fundamental of tissue engineering and regenerative medicine

(15555)

Bachelor in Biomedical Engineering (Plan: 419 - Estudio: 257)

Coordinating teacher: GUERRERO ASPIZUA, SARA

Department assigned to the subject: Bioengineering and Aeroespace Engineering Department

Type: Compulsory

ECTS Credits: 6.0 ECTS

Course: 3º

Semester: 2º

Requirements (Subjects that are assumed to be known)

The student must have coursed Cell and Molecular Biology and Biochemistry.

Objectives

Tissue engineering (TE) is a multidisciplinary field which applies the principles of life science, engineering, and basic science to the development of viable substitutes which restore, maintain, or improve the function of human tissues. This course is designed to provide a basic knowledge of Tissue and organ organization and an introduction to tissue engineering: Dynamic and structural interactions between mesenchyme and parenchyme, the role of the tissue microenvironment, stem cells, gene and cell-based therapies. Students will be required to acquire understanding and expertise from analysis of primary literature and will participate in group discusions on the status of state-of-the-art designing tissue functional units. Students will be required to use a conventional and virtual microscope to recognize and document normal and pathological structures. Students will be required to follow a SPOC (small private online course) that will intensify the knowledge acquired through the continuous evaluation. The students will carry out audiovisual presentations as a result of their research in fields related to regenerative medicine.

Skills and learning outcomes

Link to document

Description of contents: programme

Obtain an overview of tissue engineering in clinical medicine and biomedical research Understand the role of emerging technologies and engineering and life science disciplines in tissue engineering 1) Review of current status of tissue engineering and regenerative medicine Introduction to TE and overview of course objectives 2) Tissues morphological and functional units Organization of cell into higher ordered structures Dynamics of Cell-ECM Interactions Analysis of the physicochemical processes that affect limit and control cells and tissues function. - Epithelial Tissue, Connective Tissue, Muscular Tissue and Nervous Tissue 3) Systems and Organs: morphological and functional units Structural and dynamic interactions between mesenchyme and parenchyma The role of tissue microenvironment, extracellular matrix and communication by growth factors 4) Tegumentary System 5) Designing tissue functional units Stem cells and Genetic Engineering 6) Seminars on tissue recognition using virtual microscope. 7) "SPOC" about tissue engineering and regenerative medicine that wil firm up the continuous evaluation contents. 8) Audiovisual material preparation based on regenerative medicine. LABORATORY EXPERIMENTS: (Every student will perform 15 hours of practical sessions in UC3M bioengineering laboratories) a. Use of conventional microscopy for the understanding of tissue structure. b. Understand microscopic organization of Tissues into Organs and systems. c. Tissue observation and image capture. Tissue engineering. d. Histology as a diagnostic tool. e. Use of Immunohistochemical techniques.

Learning activities and methodology

The program will be divided into master classes (regular and invited lectures), discussion/problem classes (seminars) virtual microscope seminars, and the students will course a SPOC (small private online course), audiovisual material preparation based in Regenerative medicine and finally laboratory classes. Students are required to read assigned chapters/articles, or solve problems before the corresponding classes. In the discussion and problems sections, relevant scientific articles and problems will be discussed by the students and the teaching team. In the laboratory sessions students, divided in small groups will perform different experiments with the help of a supervisor and Lab guide prepared by the teaching team. Students will be required to pass an exam at the end of laboratory sessions.

Assessment System

TEACHING METHODOLOGY

Teaching methodology will be mainly based on lectures, seminars, an online course: SPOC (small private online course) and finally practical sessions. 
Students may be required to read assigned documentation before lectures and seminars. Lectures will be used by the teachers to stress and clarify some difficult or interesting points from the corresponding lesson, previously prepared by the student.  
Grading will be based on continuous evaluation tests and a final exam covering the whole subject. Help sessions and tutorial classes will be held prior to the final exam upon student's request.
Attendance to lectures and seminars is not compulsory. However, failure to attend any test will result in a mark of 0 in the corresponding continuous evaluation block (see below).

The practical sessions will consist on laboratory work (15 hours in 5 sessions) and a written test at the end of the sessions.  The attendance to 80 % of practical sessions is mandatory otherwise the score will be 0 in this item.   

GRADING: 
Total score: 10 points
Continuos evaluation: 4 points out of 10
Final exam: 6 points out of 10

CONTINUOUS EVALUATION: It accounts for up to 40% of the final score of the subject (4 points of the TOTAL SCORE), and includes two components: 
1) Continuos evaluation tests : Including at least 2 partials and assignments (VM atlas, video assesment, MOOC test...)
2) Laboratory: One written laboratory test will take place at the end of the laboratory sessions. . 
 
Attendance to at least 80% of the practical sessions is mandatory; otherwise the score will be 0 in this item. 

FINAL EXAM: The final exam will cover the whole subject (including the material learned in the laboratory sessions, seminars and SPOC) and will account for the 60 % of the final score. The minimum score in the final exam to pass the subject is 4.5 over 10, notwithstanding the mark obtained in continuous evaluation. 

EXTRAORDINARY EXAM: The mark for students attending any extraordinary examination will be:
a) 100% exam
b) 60% exam and 40% continuous evaluation if it is available in the same course.

ACADEMIC CONDUCT: Unless specified all exams will be closed-book, closed-notes, no PC or mobile phone, or anything else other than a writing implement and the exam itself. Plagiarism, cheating or other acts of academic dishonesty will not be tolerated. Any infractions what so ever will result in a failing grade as well as any other disciplinary action imposed by the University.

% end-of-term-examination 60
% of continuous assessment (assigments, laboratory, practicals...) 40

Calendar of Continuous assessment

Basic Bibliography

Langer, Robert S, Lanza, R. P., and Vacanti, Joseph. Principles of Tissue Engineering. 4th ed. . Elsevier. 2014
Mescher, Anthony L. . Junqueira's Basic Histology : Text and Atlas. 15th Ed.. McGraw-Hill. 2018
Micou, Melissa Kurtis, and Dawn M. Kilkenny. A Laboratory Course in Tissue Engineering.. CRC Press. 2013

Additional Bibliography

Fawcett, Don W., and Ronald P. Jensh. Bloom and Fawcett's Concise Histology. 2nd ed. . Arnorld. 2002
Saltzman, W. Mark. . Tissue Engineering Engineering Principles for the Design of Replacement Organs and Tissues.. Oxford OP. 2004

The course syllabus may change due academic events or other reasons.