Checking date: 20/05/2024


Course: 2024/2025

Cell and molecular biology
(19756)
Bachelor in Neuroscience (Plan: 517 - Estudio: 389)


Coordinating teacher: GUERRERO ASPIZUA, SARA

Department assigned to the subject: Bioengineering Department

Type: Basic Core
ECTS Credits: 6.0 ECTS

Course:
Semester:




Requirements (Subjects that are assumed to be known)
It is recommended but not mandatory to have studied general and human Chemistry and Genetics.
Objectives
Students will become familiar with the principles that govern cell and tissue function and the alterations associated with human diseases. They will also study and use modern cellular and molecular techniques that allow us to analyze cellular function. Students, on the other hand, will learn how to address biomedical problems, as well as search and use relevant information to find innovative solutions. To do this, they will take into account the different biomedical tools taught in this degree. To do this they will have to work in cooperative teams. In addition, they will visit hospitals and/or biomedicine and biotechnology companies where they will encounter real problems and the solutions and limitations of existing technology.
Skills and learning outcomes
Description of contents: programme
1. Gene Expression. Synthesis and processing of messenger RNAs. Post-translational modifications. Export of messengers from the nucleus to the cytoplasm. 2. Molecular machinery of translation. Aminoacylation reaction of tRNAs. Structure and assembly of ribosomes. 3. Translation of messengers. Initiation, elongation and termination factors and complexes. Post-transcriptional control mechanisms. Global regulation of protein synthesis 4. Post-translational processes. Protein folding, modifications, classification and degradation. 5. Cell cycle. 6. Organization of the eukaryotic cell. 7. Structure and composition of the plasma membrane. Transport of molecules across the membrane. 8. Extracellular matrix. Unions and cell adhesion. 9. Introduction to intracellular compartments and protein transit. Core. Cytosol. Endoplasmic reticulum. Golgi apparatus. Endosomes, lysosomes, vacuoles and peroxisomes. Vesicular traffic. Mitochondria. Microfilaments. Microtubules. Intermediate filaments. 10. Cell signaling.
Learning activities and methodology
The program will be divided into lectures (master class) and paper discussion/problem sessions (small class size) and laboratory practical classes. Students are required to read or resolve assigned chapters, articles, problems, etc., before or during the corresponding classes. Classroom lectures. Face-to-face classes: reduced (workshops, seminars, case studies). Student individual work. Laboratory session. Final exam. Seminars and lectures supported by computer and audiovisual aids. Practical learning based on cases and problems, and exercise resolution. Individual and group or cooperative work with the option of oral or written presentation. Individual and group tutorials to resolve doubts and queries about the subject. Internships and directed laboratory activities.
Assessment System
  • % end-of-term-examination 60
  • % of continuous assessment (assigments, laboratory, practicals...) 40

Calendar of Continuous assessment


Extraordinary call: regulations
Basic Bibliography
  • Bruce Alberts et al. . Essential Cell Biology, 3rd Edition. Garland Publishing, Inc. New York and London.
  • J. Sambrook, E.F. Fritash and T. Maniatis. . Molecular Cloning: A laboratory Manual, 3rd Edition.. Ed. Cold Spring Harbour Press..
Additional Bibliography
  • Harvey Lodish et al. . Molecular Cell Biology, 5th Edition.. Ed. Freeman and Company, New York..
  • Jennie P. Mather and David Barned.. Animal Cell Culture Methods. . Ed. Associated Press.
  • John D. Bancroft and Marilyn Gamble. . Theory and Practice of Histological Techniques. . 5th edition.

The course syllabus may change due academic events or other reasons.